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Antimetastatic effect of amiloride in an animal tumour model
J A Kellen1, A Mirakian, A Kolin
1Department of Clinical Biochemistry, Sunnybrook Medical Centre, University of Toronto, Ontario, Canada.
Anticancer Research
|November 1, 1988
Abstract:
The diuretic Amiloride competitively inhibits the catalytic activity of the urokinase-type plasminogen activator on plasminogen in vitro. This effect was tested on a rat adenocarcinoma model and its invasive potential in the host lung. While the inhibitory effect on intact cell cultures of the tumour was slight, continuous exposure of tumour-injected animals to the drug completely prevented the formation of lung metastasis.