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Oral medullary plasmacytoma: Rare case reports
Malathi Narasimhan1, Ravindran Chinnaswamy2, G V V Giri2
1Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Journal of Oral and Maxillofacial Pathology : JOMFP
|March 20, 2020
Summary
Medullary plasmacytoma (MP), a rare plasma cell proliferation, typically affects long bones and vertebrae, causing local symptoms. This report details two unusual oral MP cases, highlighting the need for awareness in differential diagnoses.
Area of Science:
- Hematopathology
- Oncology
- Radiology
Background:
- Medullary plasmacytoma (MP), also known as solitary bone plasmacytoma, is a rare hematologic malignancy characterized by plasma cell proliferation.
- It typically manifests in active hematopoietic sites like long bones and vertebrae, presenting with localized symptoms such as pain, paresthesia, and pathological fractures.
Observation:
- Diagnostic criteria for MP include characteristic 'punched-out' bone lesions on imaging, presence of monoclonal plasma cells, and detection of M protein in serum or urine.
- While generally radiosensitive, treatment may involve combined modalities including radiation, surgery, and chemotherapy.
Findings:
- This study reports two rare cases of oral medullary plasmacytoma with atypical clinical presentations.
- The oral cavity is an uncommon site for MP, making these cases particularly noteworthy for their unusual clinical course.
Implications:
- The findings underscore the importance of considering medullary plasmacytoma in the differential diagnosis of bone tumors, especially in the oral region.
- Long-term follow-up is crucial for patients diagnosed with MP due to its potential for progression or recurrence.
