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Related Concept Videos

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Assessment of the Mouth01:26

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Pigmentation01:19

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A 3D Organotypic Melanoma Spheroid Skin Model
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Oral malignant melanoma.

Sahana Ashok1, Srikanth Damera2, Siva Ganesh2

  • 1Department of Oral and Maxillofacial Pathology, GSL Dental College, Rajahmundry, Andhra Pradesh, India.

Journal of Oral and Maxillofacial Pathology : JOMFP
|March 20, 2020
PubMed
Summary
This summary is machine-generated.

Oral malignant melanoma, a rare head and neck cancer, often presents asymptomatically. Early dental identification of pigmented oral lesions is crucial for improving the poor prognosis associated with this cancer.

Keywords:
Histopathologyimmunohistochemistryoral malignant melanomatumor-node-metastasis staging

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Area of Science:

  • Oral oncology
  • Dermatology
  • Head and neck cancer research

Background:

  • Malignant melanoma of the head and neck is a rare malignancy.
  • Oral malignant melanomas account for a small fraction of these cases, with an incidence of approximately 4 per 10 million population annually.
  • These tumors originate from epidermal melanocytes.

Observation:

  • Oral malignant melanomas most commonly occur on the palate and maxillary gingiva.
  • Initial presentation is often asymptomatic, progressing to pain, ulceration, bleeding, tooth mobility, paresthesia, and ill-fitting dentures.
  • Delayed diagnosis is frequent due to the lesion's silent growth pattern.

Findings:

  • Oral malignant melanomas exhibit invasive and metastatic tendencies, leading to a poor prognosis.
  • The case report highlights the significance of dentists in recognizing pigmented oral lesions.
  • Early detection is critical for patient outcomes.

Implications:

  • Emphasizes the critical role of dental professionals in the early detection of oral cancers.
  • Underscores the need for increased awareness among clinicians regarding the signs and symptoms of oral malignant melanoma.
  • Suggests potential for improved patient survival rates through prompt diagnosis and treatment initiation.