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Updated: Dec 26, 2025

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Ni-catalyzed 1,2-benzylboration of 1,2-disubstituted unactivated alkenes
Seewon Joung1, Allison M Bergmann1, M Kevin Brown1
1Indiana University , Department of Chemistry , 800 E. Kirkwood Ave , Bloomington , IN 47405 , USA .
Abstract:
Nickel-catalyzed 1,2-carboboration of alkenes is emerging as a useful method for chemical synthesis. Prior studies have been limited to only the incorporation of aryl groups. In this manuscript, a method for the 1,2-benzylboration of unactivated alkenes is presented. The reaction combines readily available alkenes, diboron reagents and benzylchlorides to generate synthetically versatile products with control of stereochemistry. The utility of the products as well as the mechanistic details of the process are also presented.
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