Related Experiment Video
Updated: Dec 26, 2025
09:21
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
12.4K
Using Tenecteplase for Acute Ischemic Stroke: What Is the Hold Up?
Tony Zitek1,2, Ramsey Ataya1, Isabel Brea1,2
1Kendall Regional Medical Center, Department of Emergency Medicine, Miami, Florida.
The Western Journal of Emergency Medicine
|March 20, 2020
Summary
Tenecteplase is as effective as alteplase for acute ischemic stroke and may cause fewer bleeding complications. Physicians should consider tenecteplase for thrombolysis.
Area of Science:
- Neurology
- Pharmacology
Background:
- Alteplase is the sole FDA-approved IV thrombolytic for acute ischemic stroke.
- Emerging research indicates tenecteplase may be a viable alternative.
Purpose of the Study:
- To review the literature comparing tenecteplase and alteplase for acute ischemic stroke.
- To discuss practical considerations for using tenecteplase versus alteplase.
Main Methods:
- Narrative literature review.
- Evaluation of comparative efficacy and safety data.
Main Results:
- Tenecteplase demonstrates comparable efficacy to alteplase in neurologic improvement.
- Lower rates of bleeding complications may be associated with tenecteplase at 0.25 mg/kg.
Conclusions:
- Tenecteplase is a potentially safer and equally effective option for acute ischemic stroke thrombolysis.
- Physicians should consider tenecteplase as a preferred alternative to alteplase.
Related Concept Videos
01:30Acute Coronary Syndrome I: Introduction
593
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
593
01:16Clot Retraction and Fibrinolysis
8.1K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
8.1K
01:30Acute Coronary Syndrome III: Diagnostic Studies
150
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
150
01:29Venous Thrombosis III: Interprofessional Care
220
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
220
01:22Formation of the Platelet Plug
8.4K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
8.4K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
1.5K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.5K