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Updated: Dec 25, 2025
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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Migraine Pathophysiology.
William Qubty1, Irene Patniyot2
1Pediatric Headache Center, Department of Neurology, Dell Medical School at the University of Texas at Austin, Austin, Texas.
Pediatric Neurology
|March 21, 2020
Summary
Migraine, a leading cause of disability, involves distinct phases: premonitory, aura, headache, and postdrome. Understanding these neurological stages, including hypothalamic and cortical spreading depolarization, aids migraine management.
Area of Science:
- Neurology
- Neuroscience
Background:
- Migraine is a significant cause of disability, particularly in adults aged 15-49.
- Understanding of this complex neurological disorder has evolved considerably over the past 30 years.
Purpose of the Study:
- To review the characterized phases of migraine.
- To explore the neuroanatomical, chemical, and neuroimaging correlates of each migraine phase.
Main Methods:
- Review of current scientific literature on migraine pathophysiology.
- Analysis of findings from behavioral changes and functional neuroimaging studies.
- Examination of implicated neuropeptides and neuronal mechanisms.
Main Results:
- The premonitory phase suggests hypothalamic involvement.
- Migraine aura is linked to cortical spreading depolarization.
- The headache phase involves trigeminocervical complex activation, with calcitonin gene-related peptide as a therapeutic target.
- The postdrome phase includes various neuropsychiatric and sensory symptoms.
Conclusions:
- Elucidating migraine phase mechanisms improves comprehension of migraine symptomatology.
- This understanding can assist in evaluating novel therapeutics for migraine management.
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