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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Pathophysiology of Diabetes01:20

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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RNA Interference01:23

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
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Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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Related Experiment Video

Updated: Dec 25, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

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Interactions Among Non-Coding RNAs in Diabetic Nephropathy.

Tamil Selvi Loganathan1, Siti Aishah Sulaiman1, Nor Azian Abdul Murad1

  • 1UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Frontiers in Pharmacology
|March 21, 2020
PubMed
Summary

Noncoding RNAs (ncRNAs), including microRNAs, long noncoding RNAs, and circular RNAs, are crucial in diabetic nephropathy (DN) progression. Understanding their interactions offers new diagnostic and therapeutic strategies for this kidney disease.

Keywords:
biomarkerscircRNAdiabetic nephropathykidney diseaselncRNAmiRNA

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Area of Science:

  • * Nephrology
  • * Molecular Biology
  • * Genetics

Background:

  • * Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD), posing significant clinical and economic challenges.
  • * Current treatments for DN are limited, highlighting the need for novel therapeutic targets and biomarkers.
  • * Noncoding RNAs (ncRNAs) have emerged as critical regulators in DN pathogenesis.

Purpose of the Study:

  • * To review and discuss the role of various ncRNAs in the progression of diabetic nephropathy.
  • * To explore the interactions between different ncRNAs and their impact on key genes involved in DN.
  • * To elucidate the regulatory networks of ncRNAs for potential biomarker and therapeutic target identification.

Main Methods:

  • * Comprehensive literature review of studies investigating ncRNAs in diabetic nephropathy.
  • * Analysis of reported dysregulation of microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) in DN.
  • * Examination of documented interactions among ncRNAs and with critical genes in DN.

Main Results:

  • * Dysregulation of specific miRNAs, lncRNAs, and circRNAs has been observed in DN patients and animal models.
  • * These ncRNAs interact with each other and with target genes, influencing crucial pathways in DN development.
  • * Identified ncRNAs show potential as biomarkers for DN diagnosis and as targets for novel therapies.

Conclusions:

  • * ncRNAs play a significant role in the molecular mechanisms underlying diabetic nephropathy.
  • * Understanding the ncRNA regulatory network is key to developing effective diagnostic and therapeutic strategies for DN.
  • * Targeting ncRNAs presents a promising avenue for future DN treatment and management.