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Ca2+ mediates extracellular vesicle biogenesis through alternate pathways in malignancy

Jack Taylor1, Iman Azimi2, Gregory Monteith3,4,5

  • 1Discipline of Pharmacy, Graduate School of Health, The University of Technology Sydney, Australia.

Journal of Extracellular Vesicles
|March 21, 2020
PubMed
Summary

Calcium signaling regulates extracellular vesicle (EV) production, which is elevated in cancer cells. Understanding EV biogenesis mechanisms is key to targeting cancer multidrug resistance (MDR).

Keywords:
BiogenesisSERCAcalciumcancerendoplasmic reticulumextracellular vesiclesmicrovesiclesmultidrug resistancesarco/endoplasmic reticulum calcium ATPasestore operated calcium entry

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