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Updated: Dec 25, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
A strategy to construct fluorescent non-aromatic small-molecules: hydrogen bonds contributing to the unexpected
Ruifang Guan1, Baoli Dong, Cui Xu
1School of Materials Science and Engineering, Institute of Fluorescent Probes for Biological Imaging, University of Jinan, Jinan, Shandong 250022, China. mse_guanrf@ujn.edu.cn weiyinglin2013@163.com.
Abstract:
Propanedioyl dihydrazide (PDH), traditionally believed to be non-fluorescent, was first discovered to emit substantial fluorescence in both the solid state and solvents. Then, significantly, a novel strategy is provided: fluorescent non-aromatic small molecules with rigid molecular structures could be constructed by forming hydrogen bonds.
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