Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

464
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
464
Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists01:29

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

733
Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...
733
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

527
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
527
Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

411
Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
411
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

492
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
492
Neural Regulation01:37

Neural Regulation

42.9K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
42.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Signs, signs, everywhere a sign!

Nursing·2026
Same author

Kintsugi to Build Resilience in New Nurse Residents.

Nurse educator·2025
Same author

Relationship Between Professional Quality of Life, Grit, and Compassionate Teaching in RN to BS Nursing Students.

Nurse educator·2025
Same author

Intuitive knowing for student nurses.

Nursing·2025
Same author

Kintsugi: Fosters Student Nurse Externs' and New Nurse Residents' Sense of Respect, Resilience, and Rebuilding Post Pandemic.

Dimensions of critical care nursing : DCCN·2023
Same author

Relationship Between Self-Directed Learning, Grit, and Compassionate Teaching in Doctoral Nursing Education.

Nurse educator·2023

Related Experiment Video

Updated: Dec 25, 2025

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
07:42

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

18.5K

Neuroleptic malignant syndrome: A case report.

Lisa A Ruth-Sahd1, Darris Rodrigues, Elizabeth Shreve

  • 1Lisa A. Ruth-Sahd is a professor at the York College of Pennsylvania in York, Pa., and Georgetown University in Washington, D.C. Darris Rodrigues is a nurse at St. Luke's University Health Network in Fountain Hill, Pa. Elizabeth Shreve is a nursing student at York College of Pennsylvania.

Nursing
|March 21, 2020
PubMed
Summary

Electroconvulsive therapy (ECT) offers a potential treatment for neuroleptic malignant syndrome (NMS) when standard therapies fail. This case study highlights ECT

More Related Videos

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.3K
Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
07:35

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

931

Related Experiment Videos

Last Updated: Dec 25, 2025

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
07:42

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

18.5K
Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.3K
Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
07:35

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

Published on: July 8, 2025

931

Area of Science:

  • Neuroscience
  • Psychiatry

Background:

  • Drug-resistant depression and neuroleptic malignant syndrome (NMS) pose significant clinical challenges.
  • Pharmacotherapy is the primary treatment for NMS, but some patients remain unresponsive.

Observation:

  • A case study illustrates the diagnostic process for NMS.
  • The study focuses on a patient with NMS unresponsive to conventional pharmacotherapy.

Findings:

  • Electroconvulsive therapy (ECT) demonstrated utility as a treatment for NMS in this case.
  • ECT can be a viable option for NMS patients refractory to pharmacologic interventions.

Implications:

  • ECT may be a valuable therapeutic option for select NMS patients.
  • Comprehensive nursing care is crucial for managing patients undergoing ECT for NMS.