Tritium-Labeled Compounds IV. d-Glucose-6-t, d-Xylose-5-t, and d-Mannitol-1-t

Methods are presented for the preparation of d-glucose-6-t, d-xylose-5-t, and d-mannitol-1-t by the reduction of suitable compounds with lithium borohydride-t in anhydrous tetrahydrofuran, followed by hydrolysis of the products. The starting materials for the reductions are, respectively, 1,2-O-isopropylidene-d-glucurono-6,3-lactone, 5-aldo-1,2-O-isopropylidene-d-xylo-pentofuranose, and 2,3:5,6-di-O-isopropylidene-d-mannofuranose. The apparatus and procedure for carrying out the reductions in a closed system are described.