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Is ischemia associated with the formation of White matter lesions in migraine?

Alevtina Ersoy1, Hasan Yasar1, Cuma Mertoglu2

  • 1Neurology, Erzincan Binali Yildirim University, Faculty of Medcine, Erzincan, Turkey.

Clinical Neurology and Neurosurgery
|March 21, 2020
PubMed
Abstract

Insights

Migraine patients show higher ischemia-modified albumin (IMA) and altered thiol/disulfide balance, suggesting ischemia and oxidative stress contribute to white matter lesions (WMLs). These markers may indicate WMLs formation in migraine.

Area of Science:

  • Neurology
  • Biochemistry

Background:

  • White matter lesions (WMLs) are more prevalent in migraineurs.
  • Ischemia/hypoxia and oxidative stress are implicated in WMLs development.

Purpose of the Study:

  • Investigate ischemia-modified albumin (IMA), ferroxidase, and thiol/disulfide homeostasis in migraineurs with and without WMLs.

Main Methods:

  • Included 62 migraineurs with WML, 59 without WML, and 61 controls.
  • Assessed WMLs via brain MRI (Fazekas scale).
  • Measured IMA, ferroxidase, total thiol, native thiol, and disulfide levels.

Main Results:

  • IMA levels were elevated in migraineurs, particularly those with WMLs.
  • Migraineurs without WMLs had higher total and native thiol levels.
  • Decreased disulfide levels were observed in the WML group compared to controls and non-WML groups.

Conclusions:

  • Elevated IMA suggests ischemia/hypoxia plays a role in migraine.
  • Altered thiol/disulfide homeostasis indicates an oxidant/antioxidant imbalance in migraine.
  • Ischemia/hypoxia may contribute to WMLs formation in migraine patients.
Keywords:
Ischemia-Modified albuminMigraineOxidative stressWhite matter lesionsischemia/hypoxiathiol/disulfide homeostasis

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