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Irisin and adropin decrease in preobese or obese individuals with nonalcoholic fatty liver disease.

Cuma Mertoğlu1,2, Yaprak Şule Örek2, Bülent Albayrak3

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Turkish Journal of Medical Sciences
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Summary
This summary is machine-generated.

Serum irisin and adropin levels are lower in individuals with nonalcoholic fatty liver disease (NAFLD), regardless of severity. These findings suggest a role for these hormones in NAFLD development and progression in obese adults.

Keywords:
Nonalcoholic fatty liver diseaseadropinatherogenic indexhematological parametersirisin

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Area of Science:

  • Metabolic disease research
  • Hormone function in obesity
  • Liver health and disease

Background:

  • Nonalcoholic fatty liver disease (NAFLD) is a metabolic condition frequently associated with obesity.
  • Irisin and adropin are hormones implicated in metabolic regulation.

Purpose of the Study:

  • To investigate serum irisin and adropin levels in preobese or obese adults with varying degrees of NAFLD.
  • To explore the relationship between these hormone levels and NAFLD severity.

Main Methods:

  • Study included 89 participants categorized into four groups: normal-weight controls, preobese/obese without NAFLD, and preobese/obese with Grade 1 or Grade 2-3 NAFLD.
  • Abdominal ultrasonography, anthropometric assessments, and serum hormone level determination via ELISA were performed.

Main Results:

  • Serum adropin and irisin levels were significantly lower in NAFLD patients (Grades 1-3) compared to normal-weight controls.
  • Hormone levels did not differ significantly between NAFLD severity groups (Grade 1 vs. Grades 2-3).
  • Elevated atherogenic index and red cell distribution width were observed in NAFLD groups.

Conclusions:

  • Decreased serum adropin and irisin levels are associated with the presence of NAFLD in preobese and obese individuals.
  • These hormonal changes may contribute to the development and worsening of NAFLD.
  • Further research is warranted to elucidate the precise mechanisms involved.