Indole alkaloids: 2012 until now, highlighting the new chemical structures and biological activities

Indole alkaloids have attracted attention because of their therapeutic properties, being anti-inflammatory, antinociceptive, antitumoural, antioxidant and antimicrobial. These compounds present a wide structural diversity, which is directly related to the genera of the producing plants, as well as the biological activities. Indole alkaloids have attracted attention over the last decade because of this combination of bioactivity and structural diversity. Therefore, this review presented recent (2012-2018) advances in alkaloids, focusing on new compounds, extraction methods and biological activities. As such, approximately 70 articles were identified, which showed 261 new compounds produced by plants of the families Apocynaceae, Rubiaceae, Annonaceae and Loganiaceae. In addition, different extraction methods were identified, and the structures of the new compounds were analysed. In addition to indole molecules, there were mono-indole-, di-indole-, vinblastine-, vimblastine-, gelsedine-, geissospermidine-, koumine-, geissospermidine-, iboga-, perakine-, corynanthe-, vincamine-, ajmaline-, aspidorpema-, strychnos-type, β-carboline alkaloids and indole alkaloid glucosides. The reported biological activities are mainly anticancer, antibacterial, antimalarial, antifungal, antiparasitic, and antiviral, as well as anti-acetylcholinesterase and anti-butyrylcolinesterase properties. This review serves as a guide for those wishing to find the most recently identified alkaloid structures and their associated activities.