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Updated: Dec 25, 2025

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion

Published on: November 28, 2025

Pediatric donor management to optimize donor heart utilization.

Daniel Zimpfer¹, Peta M A Alexander², Ryan R Davies³

¹Department of Cardiac Surgery, Pediatric Heart Center Vienna, Vienna, Austria.

Pediatric Transplantation

|March 22, 2020

Summary

Optimizing pediatric donor management, including monitoring and hormonal therapy, is crucial for maximizing the use of donor hearts and reducing organ discard. This review outlines current best practices for pediatric cardiac donors.

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Last Updated: Dec 25, 2025

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Published on: November 28, 2025

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Area of Science:

Cardiology
Transplantation Medicine
Pediatric Critical Care

Background:

Pediatric donor heart utilization is suboptimal, with a high rate of organ discard.
Effective management of pediatric cardiac donors is critical for maximizing organ availability.

Purpose of the Study:

To provide a comprehensive overview of current practices and guidelines for the optimal management of pediatric cardiac donors.
To identify strategies for maximizing donor heart utilization and minimizing organ discard.

Main Methods:

Systematic literature review of current practices and guidelines for pediatric donor management.
Analysis of evidence regarding donor monitoring, workup, hormonal replacement, and management of brain death effects.

Main Results:

Current practices for pediatric donor management vary, impacting organ utilization.
Evidence supports specific protocols for hormonal replacement and catecholamine support.
Addressing brain death sequelae is key to preserving organ viability.

Conclusions:

Standardized management protocols for pediatric cardiac donors are needed.
Optimized donor management can significantly increase the utilization of pediatric donor hearts.
Improved strategies will reduce the rate of discarded pediatric donor organs.