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Updated: Dec 25, 2025
Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
Absence of FGFR3-TACC3 rearrangement in hematological malignancies with numerical chromosomal alteration
C Banella1, M Ginevrino2, G Catalano1
1Neuro-oncohematology Unit, IRCCS Santa Lucia Foundation, Rome, Italy; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Abstract:
FGFR-TACC, found in different tumor types, is characterized by the fusion of a member of fibroblast grown factor receptor (FGFR) tyrosine kinase (TK) family to a member of the transforming acidic coiled-coil (TACC) proteins. Because chromosome numerical alterations, hallmarks of FGFR-TACC fusions are present in many hematological disorders and there are no data on the prevalence, we studied a series of patients with acute myeloid leukemia and myelodysplastic syndrome who presented numerical alterations using cytogenetic traditional analysis. None of the analyzed samples showed FGFR3-TACC3 gene fusion, so screening for this mutation at diagnosis is not recommended.
