Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

4.8K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.8K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

356
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
356
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

3.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Normal life expectancy after all-trans retinoic acid and arsenic trioxide for acute promyelocytic leukemia.

Leukemia·2026
Same author

Erythroid-stimulating agents in VEXAS syndrome: A retrospective study from an Italian multicentre cohort.

British journal of haematology·2025
Same author

Acute Promyelocytic Leukemia-like AML: Genetic Perspective and Clinical Implications.

Cancers·2025
Same author

Diagnostic capabilities, clinical features, and longitudinal UBA1 clonal dynamics of a nationwide VEXAS cohort.

American journal of hematology·2023
Same author

Therapy-Related Myeloid Neoplasms: Predisposition and Clonal Evolution.

Mediterranean journal of hematology and infectious diseases·2023
Same author

Natural history of Ras-associated autoimmune leukoproliferative disorder: A 20-year follow-up of a NRAS-mutated patient excluding a malignant progression.

British journal of haematology·2023

Related Experiment Video

Updated: Jul 16, 2025

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

1.3K

Bone Marrow Microenvironment Involvement in t-MN: Focus on Mesenchymal Stem Cells.

Giulia Falconi1, E Galossi1, H Hajrullaj1

  • 1Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.

Mediterranean Journal of Hematology and Infectious Diseases
|September 14, 2023
PubMed
Summary

Therapy-related myeloid neoplasms (t-MN) arise from cytotoxic therapy complications. Bone marrow mesenchymal stem cells (BM-MSCs) dysfunction contributes to t-MN by altering the bone marrow microenvironment and supporting malignant hematopoiesis.

Keywords:
Bone marrow MicroenvironmentMesenchymal stem cellst-MN

More Related Videos

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

11.8K
An Enzymatic Method to Rescue Mesenchymal Stem Cells from Clotted Bone Marrow Samples
08:58

An Enzymatic Method to Rescue Mesenchymal Stem Cells from Clotted Bone Marrow Samples

Published on: April 12, 2015

9.3K

Related Experiment Videos

Last Updated: Jul 16, 2025

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

1.3K
Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

11.8K
An Enzymatic Method to Rescue Mesenchymal Stem Cells from Clotted Bone Marrow Samples
08:58

An Enzymatic Method to Rescue Mesenchymal Stem Cells from Clotted Bone Marrow Samples

Published on: April 12, 2015

9.3K

Area of Science:

  • Hematology
  • Oncology
  • Stem Cell Biology

Background:

  • Therapy-related myeloid neoplasms (t-MN) are a late complication of cytotoxic therapy (CT).
  • Historically, t-MN was attributed solely to DNA damage in hematopoietic stem/progenitor cells (HSPC).
  • Emerging evidence implicates the bone marrow microenvironment (BMM), particularly bone marrow mesenchymal stem cells (BM-MSCs), in t-MN pathogenesis.

Purpose of the Study:

  • To review the role of BM-MSCs in the pathogenesis of therapy-related myeloid neoplasms (t-MN).
  • To explore how CT affects BM-MSC function and contributes to malignant hematopoiesis.
  • To summarize observed alterations in BM-MSCs from t-MN patients.

Main Methods:

  • Literature review focusing on the role of BM-MSCs in t-MN.
  • Analysis of studies investigating BM-MSC function in the context of cytotoxic therapy.
  • Comparison of BM-MSC characteristics in t-MN patients versus healthy controls.

Main Results:

  • Chemo/radiotherapy can damage BM-MSCs, altering their function and promoting inflammation and malignant hematopoiesis.
  • BM-MSCs from t-MN patients exhibit reduced proliferation, altered morphology, increased senescence, and impaired support for HSCs.
  • Defective osteogenic differentiation and immune-regulatory properties are observed in t-MN-associated BM-MSCs.

Conclusions:

  • BM-MSCs are critical players in t-MN pathogenesis, contributing beyond direct DNA damage to HSPCs.
  • Dysfunctional BM-MSCs create a pro-malignant microenvironment, favoring the development of t-MN.
  • Further research into the genetic and functional profiles of t-MN-MSCs is crucial for prognostic and therapeutic advancements.