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Updated: Dec 25, 2025
09:00
Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond
Published on: July 27, 2013
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Autophagy-driven NETosis is a double-edged sword - Review
Xiaofei Liang1, Li Liu1, Yan Wang1
1Department of Laboratory Medicine, The First Hospital of Qiqihar, Qiqihar, 161005, China; Department of Laboratory Medicine, Affiliated Qiqihar Hospital, Southern Medical University, Qiqihar, 161005, China.
Summary
Autophagy influences Neutrophil Extracellular Traps (NETs) formation, impacting both infection defense and non-infectious diseases. The specific role of autophagy in NETosis depends on induction methods and extent, affecting inflammation and tissue damage.
Area of Science:
- Cellular biology
- Immunology
Background:
- Autophagy is a key cellular process for degrading damaged components and responding to stress.
- Neutrophil Extracellular Traps (NETs) are DNA structures involved in pathogen defense but can also cause damage in non-infectious diseases.
Purpose of the Study:
- To review the dual role of autophagy in the formation and function of NETs.
- To explore how autophagy-driven NETosis contributes to various diseases and host defense.
Main Methods:
- Literature review of recent studies on autophagy and NETosis.
- Analysis of distinct roles of autophagy in NETosis based on induction and extent.
Main Results:
- Autophagy can promote or inhibit NETosis, influencing inflammation, tissue damage, and cell fate.
- Autophagy-dependent NETs have both beneficial roles in pathogen clearance and detrimental roles in disease.
Conclusions:
- The specific role of autophagy in NETosis is context-dependent, varying with the extent and induction of autophagy.
- Understanding autophagy-driven NETosis is crucial for developing targeted treatments for various diseases.
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