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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

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Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
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Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

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Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
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Renal Corpuscle01:20

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
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Hormonal Regulation01:33

Hormonal Regulation

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The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
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Related Experiment Video

Updated: Dec 25, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Preeclampsia and Glomerulonephritis: A Bidirectional Association.

Vincenzo Di Leo1, Flavia Capaccio1, Loreto Gesualdo2

  • 1Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy.

Current Hypertension Reports
|March 23, 2020
PubMed
Summary

Preeclampsia (PE) can cause kidney injury and worsen glomerulonephritis (GN). Glomerulonephritis may also contribute to PE development, highlighting a complex relationship requiring further study and multidisciplinary care.

Keywords:
Chronic kidney diseaseDiabetic nephropathyFocal segmental glomerulosclerosisGlomerulonephritisIgA nephropathyLupus nephritisPreeclampsia

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Area of Science:

  • Nephrology
  • Obstetrics
  • Pathophysiology

Background:

  • Preeclampsia (PE) involves dysfunctional utero-placental perfusion leading to systemic endotheliosis.
  • An imbalance of angiogenic factors in PE causes kidney injury.

Purpose of the Study:

  • To examine how preeclampsia (PE) mediates glomerular injury and affects glomerulonephritis (GNs).
  • To discuss the role of GNs in the development of PE.

Main Methods:

  • Review of current understanding of preeclampsia and glomerulonephritis.
  • Analysis of the bidirectional correlation between PE and GNs.

Main Results:

  • PE can reveal silent pre-existing GN or induce its development.
  • GNs compromise renal function and increase PE risk due to maternal vascular inflammation.
  • PE can accelerate chronic kidney disease (CKD) progression.

Conclusions:

  • A bidirectional relationship exists between PE and GNs, though data are limited.
  • Further large-scale studies are warranted to elucidate this correlation.
  • Multidisciplinary collaboration between obstetricians and nephrologists is crucial for managing pregnant women with PE and/or GNs.