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Repair, Removal, and Shutdown: It All Hinges on RNA Polymerase II Ubiquitylation
1Center for Genomic Integrity, Institute for Basic Science, Ulsan 44919, Republic of Korea.
Cell
|March 24, 2020
Abstract:
Two papers, by Nakazawa and Vidaković, show how ubiquitylation of a single lysine residue in RNA polymerase II serves as a master switch to regulate transcription, RNA polymerase II degradation, and transcription-coupled nucleotide excision repair in response to DNA damage.
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