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Updated: Dec 25, 2025

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
Published on: June 24, 2018
Nature's remedy to phosphate woes: calciprotein particles regulate systemic mineral metabolism
Willi Jahnen-Dechent1, Edward R Smith2
1Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University Hospital, Aachen, Germany.
Abstract:
Calciprotein particles, colloidal complexes of calcium phosphate and plasma protein fetuin-A, have emerged as mediators of multiple biological effects attributed to phosphate. A new study postulates that circulating calciprotein particles, not phosphate, regulate the production of the major bone-derived phosphatonin, fibroblast growth factor-23. The signaling events coupling calciprotein particles sensing in bone to fibroblast growth factor-23 secretion remain to be established.
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