Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

306
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
306
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

301
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
301
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

351
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
351
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

291
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
291
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

149
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
149
Aortic Regurgitation IV: Nursing Management01:17

Aortic Regurgitation IV: Nursing Management

219
A nurse managing a patient with aortic regurgitation begins with a comprehensive assessment, including a review of the patient's medical history, family history, and lifestyle factors. During the cardiac examination, the nurse listens for heart sounds and checks for signs of valve abnormalities. The nurse also observes for symptoms such as dyspnea, orthopnea, and paroxysmal nocturnal dyspnea and assesses the patient's endurance and daily activity tolerance.Based on the findings, the nurse...
219

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

USP21-mediated deubiquitylation stimulates NuMA recruitment to the cell cortex to promote mitotic spindle orientation.

Cell death and differentiation·2026
Same author

A pilot study of the effect of norepinephrine dose on left ventricular-arterial coupling in patients with septic shock.

Scientific reports·2026
Same author

The O-GlcNAc modification of PRRC2C at S2238 promotes SG formation and nasopharyngeal carcinoma metastasis.

Cellular oncology (Dordrecht, Netherlands)·2026
Same author

Clinicopathologic spectrum and outcomes of primary ovarian lymphoma: a retrospective case series.

Leukemia & lymphoma·2026
Same author

BrushEdit: All-In-One Image Inpainting and Editing.

IEEE transactions on pattern analysis and machine intelligence·2026
Same author

CRISPR/Cas12a-assisted visual and on-site detection of porcine circovirus type 2.

BMC veterinary research·2026

Related Experiment Video

Updated: Dec 25, 2025

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
06:51

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Published on: October 20, 2023

1.5K

Aortic stenosis in women.

Ying Shan1,2, Patricia A Pellikka3

  • 1Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Heart (British Cardiac Society)
|March 24, 2020
PubMed
Summary

Women with aortic stenosis (AS) show unique valve and heart responses compared to men. Understanding these sex differences is crucial for effective assessment and treatment of AS patients.

Keywords:
aortic stenosiscardiac imaging and diagnosticsechocardiographyprosthetic heart valvesvalvular heart disease

More Related Videos

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
05:31

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

Published on: May 16, 2025

706
Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.7K

Related Experiment Videos

Last Updated: Dec 25, 2025

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research
06:51

Author Spotlight: Development of a Minimally Invasive Large-Animal Model for Reliable and Reproducible Cardiovascular Research

Published on: October 20, 2023

1.5K
Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
05:31

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

Published on: May 16, 2025

706
Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.7K

Area of Science:

  • Cardiology
  • Cardiovascular Research
  • Medical Science

Background:

  • Aortic stenosis (AS) disproportionately affects aging populations, with women comprising a significant portion due to longer life expectancy.
  • Distinctive anatomical and physiological differences exist in women's stenotic aortic valves and left ventricular responses compared to men.
  • Existing research highlights sex-based variations in clinical presentation, disease progression, and treatment outcomes for AS.

Purpose of the Study:

  • To comprehensively review and synthesize current evidence on sex differences in aortic stenosis.
  • To elucidate gender-based variations in AS pathophysiology, clinical manifestations, and treatment responses.
  • To inform clinical practice and future research directions regarding sex-specific management of AS.

Main Methods:

  • Systematic review of existing literature on sex differences in aortic stenosis.
  • Analysis of data from randomized controlled trials, particularly those involving transcatheter aortic valve implantation (TAVI).
  • Evaluation of studies examining clinical presentation, anatomical variations, pathophysiology, and treatment outcomes in male and female AS patients.

Main Results:

  • Women with AS present with unique stenotic valve leaflet characteristics and compensatory left ventricular responses.
  • Evidence from TAVI trials indicates significant sex differences in both short-term and long-term post-intervention outcomes.
  • Variations observed in symptoms, disease progression, and response to interventions underscore the importance of gender-specific considerations.

Conclusions:

  • A thorough understanding of sex differences in aortic stenosis is essential for optimizing patient assessment and treatment strategies.
  • Further research is warranted to explore the full spectrum of gender-based variations in AS.
  • Tailoring management approaches based on sex-specific characteristics may improve outcomes for patients with aortic stenosis.