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Updated: Dec 25, 2025

Isolation of Cerebral Capillaries from Fresh Human Brain Tissue
Published on: September 12, 2018
The constitutive androstane receptor and pregnane X receptor in the brain
Pablo Torres-Vergara1,2,3, Yu Siong Ho4, Francisca Espinoza2
1Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepción, Concepción, Chile.
Abstract:
Since their discovery, the orphan nuclear receptors constitutive androstane receptor (CAR;NR1I3) and pregnane X receptor (PXR;NR1I2) have been regarded as master regulators of drug disposition and detoxification mechanisms. They regulate the metabolism and transport of endogenous mediators and xenobiotics in organs including the liver, intestine and brain. However, with proposals of new physiological functions for NR1I3 and NR1I2, there is increasing interest in the role of these receptors in influencing brain function. This review will summarise key findings regarding the expression and function of NR1I3 and NR1I2 in the brain, hereby highlighting the need for further research in this field.
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