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Development of Immunocompetence

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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research

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ImmunoPET: Concept, Design, and Applications.

Weijun Wei^1,2, Zachary T Rosenkrans³, Jianjun Liu¹

¹Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

Chemical Reviews

|March 24, 2020

Summary

This summary is machine-generated.

Immuno-positron emission tomography (immunoPET) combines antibody specificity with PET sensitivity for advanced cancer imaging. This technique reveals tumor markers and guides antibody drug development, improving cancer diagnostics and therapeutics.

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Murine Model of Epicutaneously-Induced Immunomodulation

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Published on: June 24, 2025

Area of Science:

Molecular Imaging
Radiochemistry
Oncology

Background:

Immuno-positron emission tomography (immunoPET) integrates monoclonal antibody (mAb) targeting with positron emission tomography (PET) sensitivity.
Development of immunoPET probes relies on advancements in radiochemistry and conjugation strategies.
Novel tumor-targeting vectors like Nanobodies and bispecific antibodies enhance immunoPET probe design.

Purpose of the Study:

To review the latest immunoPET imaging strategies and their preclinical and clinical applications.
To highlight conjugation strategies for developing next-generation immunoPET probes.
To discuss practical considerations for the development and translation of immunoPET imaging.

Main Methods:

Exploitation of various radionuclides and mAbs for immunoPET probe development.
Utilizing advanced radiochemistry and conjugation techniques.
Incorporation of novel targeting vectors such as Nanobodies and bispecific antibodies.

Main Results:

Successful clinical translation of immunoPET probes like ⁸⁹Zr-Df-pertuzumab and ⁸⁹Zr-atezolizumab.
ImmunoPET enables noninvasive, dynamic visualization of heterogeneous tumor antigen expression.
ImmunoPET provides critical data on antibody targeting and distribution in drug development.

Conclusions:

ImmunoPET imaging is transforming the theranostic landscape for malignancies by imaging tumor markers, immune cells, and inflammatory processes.
ImmunoPET is crucial for evaluating antibody drug efficacy and guiding clinical translation.
Continued optimization of strategies is essential for advancing immunoPET applications in oncology.