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Functionally graded biomimetic biomaterials in dentistry: an evidence-based update
Syed Saad Bin Qasim1,2, Muhammad Sohail Zafar3,4, Fayez Hussain Niazi5
1Faculty of Dentistry, Department of Biomaterials, University of Oslo, Blindern, Oslo, Norway.
Journal of Biomaterials Science. Polymer Edition
|March 24, 2020
Summary
Functionally graded materials mimic natural tissue, offering advanced biomaterials for dental regeneration. These innovative scaffolds, particularly those made with additive manufacturing, show promise for clinical applications in dentistry.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Dental Research
Background:
- Regenerating lost tissue structure and function is a significant clinical challenge.
- Synthetic biomaterials are advancing, incorporating biologically inspired elements.
- Functionally graded materials (FGMs) mimic natural tissue morphology for enhanced therapeutic responses.
Purpose of the Study:
- To provide an overview of the functionally graded concept in clinical dentistry.
- To explore FGMs' applications in restorative, prosthodontics, periodontics, orthodontics, and oral surgery.
- To discuss processing techniques for creating functional gradients in biomaterials.
Main Methods:
- Review of existing literature on functionally graded materials in dentistry.
- Analysis of various processing techniques including additive manufacturing, freeze gelation, freeze drying, electrospinning, and particulate leaching.
- Examination of spatiotemporal arrangement in dental applications.
Main Results:
- Functionally graded materials offer a biomimetic approach to tissue regeneration.
- Additive manufacturing (3D printing) is a powerful tool for designing and reproducing FGMs.
- Various conventional and advanced techniques can achieve functional gradients.
Conclusions:
- FGMs hold significant potential for clinical dentistry, improving tissue regeneration.
- Further research into materials and synthesis techniques will expand FGM applications.
- Biomimetic templates created using FGMs can advance dental treatments.

