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Updated: Dec 25, 2025

Multiplexing Focused Ultrasound Stimulation with Fluorescence Microscopy

Multiplexing Focused Ultrasound Stimulation with Fluorescence Microscopy

Published on: January 7, 2019

In vivo ultrasound-switchable fluorescence imaging using a camera-based system.

Shuai Yu^1,2,3, Tingfeng Yao^1,2,3, Yang Liu^1,2

¹Ultrasound and Optical Imaging Laboratory, Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA.

Biomedical Optics Express

|March 25, 2020

Summary

This study introduces a novel camera-based ultrasound-switchable fluorescence (USF) imaging system for in vivo applications. The system successfully imaged mouse glioblastoma tumors and internal organs, demonstrating its potential for preclinical research.

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Last Updated: Dec 25, 2025

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Area of Science:

Biomedical Imaging
Optical Imaging
Nanotechnology

Background:

Ultrasound-switchable fluorescence (USF) imaging offers high spatial resolution for deep tissue visualization.
Previous in vivo USF imaging relied on photomultiplier tube systems.

Purpose of the Study:

To demonstrate in vivo USF imaging using a novel camera-based system.
To evaluate USF contrast agents with varying particle sizes for biodistribution and imaging.
To compare USF imaging with micro-CT for validation.

Main Methods:

Development and implementation of a camera-based USF imaging system.
Design of USF contrast agents (70 nm and 330 nm) for targeted and systemic delivery.
In vivo imaging of glioblastoma tumors and organs (spleen, liver) in mice.
Comparison of USF imaging results with X-ray micro-CT.

Main Results:

The camera-based USF system enabled efficient 2D USF signal acquisition.
Successful in vivo USF imaging of mouse glioblastoma tumors via local injection.
USF contrast agents showed stable properties in tumors, spleen, and liver.
In vivo USF imaging of spleen and liver was achieved via intravenous injection.
USF imaging results correlated with micro-CT findings.

Conclusions:

A camera-based USF system is feasible for in vivo imaging.
USF imaging can visualize tumors and internal organs with targeted and systemically delivered contrast agents.
This technique holds promise for preclinical research and diagnostics.