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Updated: Dec 25, 2025

Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
Preoperative psychological characteristics affecting mid-term outcome after bariatric surgery: a follow-up study
Carlo Lai1, Paola Aceto2,3, Francesca Romana Santucci4
1Dynamic and Clinical Psychology Department, Sapienza University of Rome, Via degli Apuli 1, 00185, Rome, Italy. carlo.lai@uniroma1.it.
Background:
The purpose of this study was to investigate the relationship between preoperative psychological factors and percentage of total weight loss (%TWL) after laparoscopic Roux-en-Y gastric bypass (LRYGB) to identify possible psychological therapy targets to improve the outcome of bariatric surgery.
Methods:
Seventy-six patients completed the Hamilton's Anxiety and Depression Scales (HAM-A, HAM-D) and Toronto Alexithymia Scale (TAS-20) the day before surgery (T0). The pre-operative body weight and the %TWL at 3 (T1), 6 (T2), and 24-30 (T3) months were collected.
Results:
At T3, depressed and alexithymic patients showed a lower %TWL compared to non-depressed patients (p = 0.03) and to non-alexithymic patients (p = 0.02), respectively. Finally, patients who had at least one of the three analyzed psychological factors showed less weight loss, at T2 (p = 0.02) and T3 (p = 0.0004).
Conclusions:
Psychological factors may also affect long-term outcome of bariatric surgery. This study shows an association between alexithymia/depression pre-operative levels and the weight loss at 30 months'follow-up after bariatric surgery.
Level Of Evidence:
Level III, longitudinal cohort study.
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