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Stem Cell Factor Receptor Immunoexpression in Adolescent Varicocele.

Salvatore Arena1, Pietro Impellizzeri2, Carmine Fazzari3

  • 1Unit of Pediatric Surgery, Department of Human Pathology of Adult and Childhood "Gaetano Barresi", University of Messina, Messina, Italy. salarena@unime.it.

Urology Journal
|March 25, 2020
PubMed
Summary
This summary is machine-generated.

Varicocele in adolescents is linked to reduced c-kit positive germ cells and increased testicular asymmetry. This suggests c-kit may play a role in germ cell damage in varicocele, highlighting the need for better diagnostic markers.

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Area of Science:

  • Reproductive Biology
  • Andrology
  • Cell Biology

Background:

  • Stem cell factor receptor (c-kit) is vital for germ cell proliferation and survival.
  • Varicocele is a common cause of male infertility, particularly in adolescents.
  • Understanding the molecular mechanisms underlying varicocele-induced germ cell damage is crucial.

Purpose of the Study:

  • To investigate the correlation between c-kit positive germ cells, testicular asymmetry, and histological grade in adolescent varicocele.
  • To assess the relationship between testicular hypotrophy, germ cell markers, and spermatogenic failure severity.

Main Methods:

  • Analysis of 20 testicular biopsy samples from adolescents with varicocele and 8 controls.
  • Quantification of c-kit positive germ cells and assessment of testicular asymmetry and histological grade.
  • Statistical analysis using Spearman correlation to evaluate relationships between variables.

Main Results:

  • Varicocele testes showed significantly higher histological grades and lower numbers of c-kit positive germ cells compared to controls.
  • A positive correlation was found between testicular hypotrophy and histological grade.
  • A negative correlation was observed between c-kit positive germ cells and both testicular hypotrophy and histological grade.

Conclusions:

  • A significant correlation exists between testicular hypotrophy, histological lesions, and reduced c-kit positive germ cells in varicocele.
  • These findings suggest a potential role for c-kit in the pathogenesis of germ cell impairment in varicocele.
  • Further research is needed to identify reliable markers for predicting testicular function in adolescents with varicocele.