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2D nanostructures beyond graphene: preparation, biocompatibility and biodegradation behaviors
Shige Wang1, Xueqing Yang, Lingling Zhou
1College of Science, University of Shanghai for Science and Technology, No. 334 Jungong Road, Shanghai 200093, China.
Journal of Materials Chemistry. B
|March 25, 2020
Summary
Two-dimensional (2D) nanomaterials offer unique properties for nanomedicine. This review covers their preparation, biocompatibility, and biodegradation for therapeutic applications.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Two-dimensional (2D) nanomaterials are gaining attention for nanomedicine due to unique physicochemical properties.
- Their diverse biomedical applications necessitate a review of current research.
Purpose of the Study:
- To review recent advances in the preparation, biocompatibility, and biodegradation of various 2D nanomaterials.
- To discuss the prospects and challenges for developing 2D nanomaterials in biomedical applications.
Main Methods:
- Review of up-to-date research on 2D nanomaterials.
- Detailed discussion of in vitro and in vivo biocompatibility and degradation.
- Assessment of degradation via redox reactions, enzymes, pH, and cellular environment.
Main Results:
- Covers transition-metal dichalcogenides (TMDs), transition metal oxides (TMOs), black phosphorus (BP), metal-organic frameworks (MOFs), 2D boron (B), boron nitride (BN), layered double hydroxides (LDHs), and nanoscale metals.
- Discusses biocompatibility and biodegradation mechanisms in detail.
- Summarizes current research status and future directions.
Conclusions:
- 2D nanomaterials show significant promise for nanomedicine.
- Further research is needed to address challenges in their development and application.
