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Isotopic Effect in Double Proton Transfer Process of Porphycene Investigated by Enhanced QM/MM Method
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Proton Hopping in Living Systems.

Lemont B Kier1

  • 1School of Pharmacy, Department of Nurse Anesthesia, and Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, VA, United States.

Current Computer-Aided Drug Design
|March 26, 2020
PubMed
Summary
This summary is machine-generated.

Proton hopping, a water-mediated process, carries information in biological systems. This mechanism explains nerve impulses, drug-receptor interactions, sleep, anesthesia, and memory.

Keywords:
Proton hoppingagentsanestheticdrug-receptorliving systemsmolecular interaction.water

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Area of Science:

  • Biophysics
  • Physical Chemistry
  • Neuroscience

Background:

  • The Grotthuss mechanism, proposed in 1806, describes proton hopping.
  • Water's unique properties are crucial for life and biological processes.
  • Proton hopping is fundamental to understanding various life functions.

Purpose of the Study:

  • To review the mechanism of proton hopping in biological systems.
  • To explore the role of proton hopping in nerve systems, drug-receptor interactions, sleep, anesthesia, and memory.
  • To highlight the information-carrying capacity of proton hopping in water.

Main Methods:

  • Literature review of proton hopping mechanisms.
  • Analysis of proton hopping's role in physiological processes.
  • Discussion of experimental and theoretical evidence.

Main Results:

  • Proton hopping facilitates information transfer in biological systems.
  • Alterations in proton hopping are linked to sleep and the effects of general anesthetics.
  • Proton hopping plays a role in nerve signal transmission and memory formation.

Conclusions:

  • Proton hopping is a vital mechanism underlying diverse biological functions.
  • Understanding proton hopping provides insights into neurological processes and drug actions.
  • The concept of proton hopping continues to evolve as a key to life's chemistry.