Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Selection01:46

Types of Selection

43.7K
Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
43.7K
Frequency-dependent Selection01:21

Frequency-dependent Selection

22.9K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
22.9K
Limits to Natural Selection01:38

Limits to Natural Selection

33.8K
Organisms that are well-adapted to their environment are more likely to survive and reproduce. However, natural selection does not lead to perfectly adapted organisms. Several factors constrain natural selection.
33.8K
Dose-Response Relationship: Selectivity and Specificity01:25

Dose-Response Relationship: Selectivity and Specificity

9.4K
Drugs exert their therapeutic effects by interacting with receptors, enzymes, or ion channels that are present throughout the human body. The strength and duration of the interaction between a drug and its target receptor are characterized by the selectivity and specificity of the drug. Selectivity refers to a drug's strong preference for its intended target over other targets. For instance, isoprenaline, a non-selective β-adrenergic agonist, interacts with both β1- and...
9.4K
Genetic Screens02:46

Genetic Screens

5.5K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.5K
Antibiotic Selection00:57

Antibiotic Selection

59.2K
Overview
59.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Introducing synchronous robustness reports.

Nature human behaviour·2025
Same author

Registered Reports: benefits and challenges of implementing in medicine.

The British journal of general practice : the journal of the Royal College of General Practitioners·2024
Same author

Explicit and Implicit Devaluation Effects of Food-Specific Response Inhibition Training.

Journal of cognition·2023
Same author

The Restrain Food Database: validation of an open-source database of foods that should be eaten more or less as part of a healthy diet.

Royal Society open science·2022
Same author

Ten simple rules for writing a Registered Report.

PLoS computational biology·2022
Same author

Beyond online participant crowdsourcing: The benefits and opportunities of big team addiction science.

Experimental and clinical psychopharmacology·2022
Same journal

The human claustrum supports cognitive networks for externally and internally driven task demands.

PLoS biology·2026
Same journal

Unusual decay: Recombination loss leads to splicing errors in green algae.

PLoS biology·2026
Same journal

Angptl5 restricts primitive hematopoiesis by promoting retinoic acid signaling in zebrafish.

PLoS biology·2026
Same journal

Engineered bipaternal mice reveal the consequences of life without a maternal genomic contribution.

PLoS biology·2026
Same journal

Multiple adhesion molecules act together in oligodendrocyte-mediated axonal selection and myelin formation.

PLoS biology·2026
Same journal

Splicing deficiency is driven by genomic erosion in non-recombining algal mating-type chromosomes.

PLoS biology·2026
See all related articles

Related Experiment Video

Updated: Dec 25, 2025

Scalable High Throughput Selection From Phage-displayed Synthetic Antibody Libraries
12:55

Scalable High Throughput Selection From Phage-displayed Synthetic Antibody Libraries

Published on: January 17, 2015

19.1K

Frontloading selectivity: A third way in scientific publishing?

Christopher D Chambers1

  • 1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, Wales, United Kingdom.

Plos Biology
|March 27, 2020
PubMed
Summary
This summary is machine-generated.

Registered Reports offer a solution to publication bias by frontloading editorial decisions. This method evaluates research proposals for rigor, not results, ensuring reliable knowledge advancement.

More Related Videos

Author Spotlight: High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography
06:19

Author Spotlight: High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography

Published on: March 10, 2023

5.4K
A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans
08:49

A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans

Published on: March 20, 2018

9.3K

Related Experiment Videos

Last Updated: Dec 25, 2025

Scalable High Throughput Selection From Phage-displayed Synthetic Antibody Libraries
12:55

Scalable High Throughput Selection From Phage-displayed Synthetic Antibody Libraries

Published on: January 17, 2015

19.1K
Author Spotlight: High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography
06:19

Author Spotlight: High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography

Published on: March 10, 2023

5.4K
A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans
08:49

A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans

Published on: March 20, 2018

9.3K

Area of Science:

  • Scientific publishing
  • Research integrity

Background:

  • Traditional journal selectivity relies on research outcomes, leading to publication bias.
  • This selective reporting can result in misleading, biased, and unreliable scientific findings.

Purpose of the Study:

  • To introduce and advocate for frontloaded selectivity in scientific publishing.
  • To present Registered Reports as a method to maintain journal selectivity while eliminating outcome bias.

Main Methods:

  • Implementing editorial decisions based on research question and methodology evaluation before study commencement.
  • Utilizing the Registered Reports model, as exemplified by PLOS Biology's Preregistered Research Articles.

Main Results:

  • Registered Reports allow journals to uphold high standards of research importance and rigor.
  • This model effectively eliminates outcome bias from editors, reviewers, and authors.

Conclusions:

  • Frontloaded selectivity through Registered Reports can mitigate publication bias and enhance research reliability.
  • The adoption of Registered Reports by selective journals is expected to reshape research evaluation and knowledge advancement.