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Related Experiment Video

Updated: Dec 25, 2025

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
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Keratoconus Progression Classification One Year After Performed Crosslinking Method Based on ABCD Keratoconus Grading

Senad Grisevic1, Fanka Gilevska2, Alma Biscevic1,3

  • 1Eye Clinic Svjetlost, Sarajevo, Bosnia and Herzegovina.

Acta Informatica Medica : AIM : Journal of the Society for Medical Informatics of Bosnia & Herzegovina : Casopis Drustva Za Medicinsku Informatiku Bih
|March 27, 2020
PubMed
Summary

Corneal cross-linking (CXL) effectively stabilized keratoconus progression over 12 months. The ABCD grading system showed no significant changes post-procedure, indicating CXL is a safe and effective treatment for this progressive eye condition.

Keywords:
ABCD gradation systemcross linkingkeratoconuspentacam

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Area of Science:

  • Ophthalmology
  • Corneal Disorders
  • Regenerative Medicine

Background:

  • Keratoconus is a progressive, non-inflammatory corneal disease causing thinning and increased curvature.
  • Early detection and intervention are crucial for managing keratoconus progression.

Purpose of the Study:

  • To evaluate keratoconus progression one year after corneal cross-linking (CXL).
  • To assess the efficacy of CXL using the ABCD keratoconus grading system.

Main Methods:

  • Prospective study of 17 keratoconus patients (22 eyes).
  • Standard Dresden protocol for CXL performed.
  • ABCD grading system and Pentacam tomography used for pre- and post-operative comparison over 12 months.

Main Results:

  • No statistically significant keratoconus progression observed 12 months post-CXL compared to pre-operative stages.
  • The ABCD keratoconus grading system showed stable results.
  • No adverse events reported, confirming CXL safety.

Conclusions:

  • Corneal cross-linking (CXL) effectively stabilizes keratoconus progression.
  • CXL is a safe and effective treatment option for keratoconus patients.
  • The ABCD grading system is a reliable tool for assessing CXL outcomes.