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Updated: Dec 25, 2025

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method
Published on: December 20, 2024
Carbon-11 carboxylation of trialkoxysilane and trimethylsilane derivatives using [11C]CO2
Salvatore Bongarzone1, Nicola Raucci, Igor Camargo Fontana
1School of Biomedical Engineering & Imaging Sciences, King's College London, King's Health Partners, St Thomas' Hospital, London SE1 7EH, UK. salvatore.bongarzone@kcl.ac.uk antony.gee@kcl.ac.uk.
Abstract:
A novel carboxylation radiosynthesis methodology is described starting from cyclotron-produced [11C]CO2 and fluoride-activated silane derivatives. Six carbon-11 labelled carboxylic acids were obtained from their corresponding trimethylsilyl and trialkoxysilyl precursors in a one-pot labelling methodology. The radiochemical yields ranged from 19% to 93% within 12 minutes post [11C]CO2 delivery with a trapping efficiency of 21-89%.
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