Related Experiment Video

Updated: Dec 25, 2025

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

Published on: October 7, 2025

256

Intercalating the Role of MicroRNAs in Cancer: As Enemy or Protector

Tapan Behl1, Chanchal Kumar2, Rashita Makkar1

  • 1Chitkara College of Pharmacy, Chitkara University, Punjab, India.

Asian Pacific Journal of Cancer Prevention : APJCP
|March 28, 2020
PubMed
Abstract

Insights

MicroRNAs (miRNAs) are key regulators in cancer development, influencing cellular processes and gene expression. This review explores their potential as therapeutic agents for managing cancer by targeting genetic transformations.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer arises from genetic alterations leading to uncontrolled cell proliferation.
  • MicroRNAs (miRNAs) play a crucial role in regulating cellular processes relevant to cancer development.

Purpose of the Study:

  • To review the role of miRNAs in cancer management.
  • To highlight how miRNAs alter cellular processes to combat cancer.

Main Methods:

  • Comprehensive literature search on miRNAs in cancer.
  • Data collection from medical databases like PubMed and MEDLINE.
  • Focus on English-language articles.

Main Results:

  • Cancer development involves multiple genetic factors, including oncogenes and tumor suppressor genes.
  • Metastasis, driven by epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET), is a critical challenge in cancer progression.
  • Understanding gene alterations and tumorogenesis mechanisms is vital for cancer management.

Conclusions:

  • miRNAs offer a promising avenue for novel cancer treatment therapies.
  • Targeting altered genes and their mechanisms can help manage cancer at various stages.
Keywords:
ApoptosisLeukemiaMetastasisTumor suppressor genescarcinogenic

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