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[Regional left ventricular diastolic dysfunction in patients with apical hypertrophy]
1First Department of Internal Medicine, Osaka City University Medical School.
Journal of Cardiology
|March 1, 1988
Summary
Apical hypertrophy (APH) affects cardiac function differently in the left ventricle's apical region compared to the chordal region. The study found prolonged filling times in the apical region of APH patients, indicating localized functional changes.
Area of Science:
- Cardiology
- Cardiac Physiology
- Echocardiography
Context:
- Apical hypertrophy (APH) is a condition affecting the left ventricle.
- Understanding regional cardiac function differences is crucial for APH management.
- M-mode echocardiography is a key diagnostic tool.
Purpose:
- To investigate regional differences in cardiac function between apical and chordal parts of the left ventricle in patients with APH.
- To compare these functional parameters with normal controls.
Summary:
- This study compared cardiac function in the apical and chordal regions of the left ventricle in 10 APH patients and 10 controls using M-mode echocardiography.
- No significant differences in overall ventricular dimensions or chordal function were observed.
- However, the apical region in APH patients showed a trend towards increased peak negative dD/dt and significantly prolonged time to peak filling rate (TPFR).
Impact:
- Findings highlight localized functional impairment in the apical region of the left ventricle in APH.
- Suggests that echocardiographic assessment of regional cardiac function is important in APH.
- Provides insights into the pathophysiology of APH, potentially guiding therapeutic strategies.