Evolving therapeutic goals in Crohn's disease management
Thomas Chateau1,2, Laurent Peyrin-Biroulet2
1FDepartment of Hepato-Gastroenterology, University Hospital of Grenoble, University of Grenoble Alpes, Grenoble, France.
United European Gastroenterology Journal
|March 28, 2020
Summary
Achieving remission in Crohn's disease requires tight control and treat-to-target strategies. Close monitoring of symptoms and inflammation can modify the disease course for better quality of life.
Area of Science:
- Gastroenterology and immunology
- Inflammatory bowel disease research
Background:
- Crohn's disease management aims to prevent complications and enhance patient quality of life.
- Historical treatment paradigms have evolved from focusing on clinical response to achieving full remission.
Observation:
- Modern Crohn's disease management emphasizes early disease control and rigorous monitoring.
- The shift towards remission necessitates tracking both patient-reported symptoms and objective inflammatory markers.
Findings:
- Tight control and treat-to-target approaches are central to current Crohn's disease strategies.
- These strategies involve setting specific therapeutic targets and closely monitoring patient progress.
Implications:
- Implementing tight control and treat-to-target may alter the long-term trajectory of Crohn's disease.
- This approach holds potential for improved disease modification and sustained remission.
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