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Updated: Dec 25, 2025
Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
Published on: March 7, 2022
Roxadustat Markedly Reduces Myocardial Ischemia Reperfusion Injury in Mice
Hiroko Deguchi1, Masataka Ikeda1, Tomomi Ide2
1Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University.
Background:
Ischemic preconditioning (IPC) is an effective procedure to protect against ischemia/reperfusion (I/R) injury. Hypoxia-inducible factor-1α (Hif-1α) is a key molecule in IPC, and roxadustat (RXD), a first-in-class prolyl hydroxylase domain-containing protein inhibitor, has been recently developed to treat anemia in patients with chronic kidney disease. Thus, we investigated whether RXD pretreatment protects against I/R injury.
Methods And Results:
RXD pretreatment markedly reduced the infarct size and suppressed plasma creatinine kinase activity in a murine I/R model. Analysis of oxygen metabolism showed that RXD could produce ischemic tolerance by shifting metabolism from aerobic to anaerobic respiration.
Conclusions:
RXD pretreatment may be a novel strategy against I/R injury.
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