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Updated: Dec 25, 2025

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
Fulminant Type 1 Diabetes with Diversity in Peripheral Blood Lymphocytes: A Case Report
Akira Kurozumi1, Yosuke Okada1, Yusuke Miyazaki1
1First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
Abstract:
A 29-year-old woman was admitted to our hospital for treatment of fulminant type 1 diabetes (FT1D) with diabetic ketoacidosis. The phenotype of peripheral blood lymphocytes was analyzed using an 8-color flow cytometer. An analysis of the CD4-positive T cells showed a tendency for higher proportions of effector and central memory T cells and a normal proportion of regulatory T (Treg) cells, compared to healthy control. An analysis of B cell differentiation showed higher proportions of switched memory B cells and plasmablasts. The differences in lymphocyte phenotypes between our case and previously reported cases suggest a diversity of FT1D pathology.
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