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Lysogenic Cycle of Bacteriophages00:43

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Bacteriophage Effectiveness for Biocontrol of Foodborne Pathogens Evaluated via High-Throughput Settings
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Bacteriophage Therapy: Developments and Directions.

Mikeljon P Nikolich1, Andrey A Filippov1

  • 1Wound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Antibiotics (Basel, Switzerland)
|March 28, 2020
PubMed
Summary
This summary is machine-generated.

Bacteriophage therapeutics offer a novel solution to combat rising multidrug-resistant bacterial infections. This review explores their development and potential for widespread clinical use, particularly fixed phage cocktails.

Keywords:
antimicrobialbacteriophage therapymultidrug resistancephage cocktail

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Multidrug-resistant bacterial infections pose a significant global health threat.
  • Existing antibiotics are becoming less effective, and new drug development is slow.
  • Bacteriophage therapeutics present a promising alternative or adjunct treatment.

Purpose of the Study:

  • To review the current status of bacteriophage therapeutic development.
  • To discuss the implementation of phage therapy in Western medicine.
  • To focus on fixed phage cocktail therapeutics as a viable near-term option.

Main Methods:

  • Literature review of bacteriophage therapy research and development.
  • Analysis of the properties and potential applications of bacteriophages.
  • Discussion of regulatory and clinical implementation pathways.

Main Results:

  • Bacteriophages have distinct properties compared to traditional antibiotics.
  • Phage therapy can be used synergistically with existing antibiotics.
  • Fixed phage cocktails are identified as a likely first wave of licensed products.

Conclusions:

  • Bacteriophage therapeutics are a critical emerging option for treating resistant infections.
  • Further development and regulatory pathways are needed for broad clinical adoption.
  • Fixed phage cocktails represent a pragmatic approach to introducing phage therapy into mainstream medicine.