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Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability

Yusuke Matsuno1,2, Yuko Atsumi1, Md Alauddin3

  • 1Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Scientific Reports
|March 28, 2020
PubMed

Insights

Resveratrol, a polyphenol, enhances genome stability by reducing DNA double-strand breaks and protecting against cancer-driving mutations. This suggests polyphenols may help suppress cancer and extend lifespan.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Genomic instability is linked to cancer development and mutations in critical genes.
  • Mechanisms maintaining genome stability are not fully understood.
  • Resveratrol and related polyphenols are plant compounds with potential health benefits.

Purpose of the Study:

  • To investigate the effect of resveratrol on genome stability.
  • To determine if resveratrol protects against mutations in cancer-related genes.
  • To explore the role of resveratrol in DNA repair pathways.

Main Methods:

  • Treatment of mouse embryonic fibroblasts with resveratrol.
  • Assessment of DNA double-strand breaks (DSBs) and mutations in the ARF/p53 pathway.
  • Analysis of histone H2AX expression as a marker for DSB repair.

Main Results:

  • Resveratrol significantly enhanced genome stability in mouse embryonic fibroblasts.
  • Resveratrol treatment reduced the accumulation of replication stress-associated DSBs.
  • Resveratrol protected against mutations in the ARF/p53 pathway and stabilized histone H2AX expression.
  • Related polyphenols demonstrated similar genome-stabilizing effects.

Conclusions:

  • Resveratrol and related polyphenols promote genome stability.
  • Polyphenol consumption may contribute to cancer suppression in genomically unstable cancers.
  • These findings suggest a potential role for polyphenols in lifespan extension.

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