Synthesis, characterization, and antiviral activity of novel fluorinated isatin derivatives
Samir Y Abbas1, Awatef A Farag2,3, Yousry A Ammar4,3
11Organometallic and Organometalloid Chemistry Department, National Research Centre, Cairo, Egypt.
Monatshefte Fur Chemie
|March 28, 2020
Abstract:
New series of Schiff's bases, hydrazones, thiosemicarbazones, thiazoles, and thiocarbohydrazones of 5-fluoroisatin were synthesized by the reaction of 5-fluoroisatin with primary amines, hydrazine hydrate, and thiocarbohydrazides. Thiosemicarbazones were prepared by reacting hydrazone derivatives with isothiocyanates. Upon treatment of thiosemicarbazone derivatives with chloroacetone, the thiazole derivatives were obtained. Some of the prepared compounds exhibited antiviral activity.


