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Updated: Dec 25, 2025
09:22
Absolute Quantitation of Inositol Pyrophosphates by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry
Published on: August 13, 2021
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Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules
Akruti Shah1,2, Shubhra Ganguli1,2, Jayraj Sen1,2
11Laboratory of Cell Signalling, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, Telangana India.
Journal of the Indian Institute of Science
|March 28, 2020
Summary
Inositol pyrophosphates (PP-IPs) are vital signaling molecules in eukaryotic cells. This review details their diverse roles in cellular processes, metabolism, and development.
Area of Science:
- Cellular Biology
- Biochemistry
Background:
- Inositol pyrophosphates (PP-IPs) are energy-rich signaling molecules ubiquitous in eukaryotic cells.
- They are inositol derivatives with diphosphate groups, including diphosphoinositol pentakisphosphate (IP7) and bis-diphosphoinositol tetrakisphosphate (IP8).
Purpose of the Study:
- To review the known functions of PP-IPs.
- To highlight their temporal and spatial distribution in eukaryotic cells.
Main Methods:
- Literature review of PP-IPs functions and distribution.
- Analysis of PP-IPs mechanisms of action: binding and pyrophosphorylation.
Main Results:
- PP-IPs modulate protein function through direct binding or pyrophosphorylation of serine residues.
- These modifications alter protein activity, localization, and interactions.
- PP-IPs are involved in diverse metabolic, developmental, and signaling pathways.
Conclusions:
- PP-IPs are crucial regulators of cellular processes across all eukaryotic organisms.
- Understanding PP-IPs' functions and distribution is key to deciphering complex cellular signaling networks.
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