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Updated: Dec 25, 2025

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents
Kiran Gangarapu1,2, Sarangapani Manda3, Anvesh Jallapally4
1Department of Pharmaceutical Chemistry, Kakatiya Institute of Pharmaceutical Sciences, Pembarthy (V), Hasanparthy (M), Warangal, 506 371 AP India.
Abstract:
A series of new β-isatin aldehyde-N,N'-thiocarbohydrazone, bis-β-isatin thiocarbohydrazones, bis-β-isatin carbohydrazones was synthesized by condensation of 5-substituted isatin with thiocarbohydrazide or carbohydrazide. The chemical structures of the newly synthesized compounds were confirmed by FT-IR, 1H NMR, and mass spectral analysis. The synthesized compounds were evaluated for in vitro antiviral activity against various strains of DNA and RNA viruses, but exhibited moderate antiviral activity compared with the reference compounds. Among all the compounds 6c exhibited the highest chemoprevention activity in a two-stage mouse-skin carcinogenesis test.
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