Related Experiment Video
Updated: Dec 25, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis, antitubercular and anticancer activity of new Baylis-Hillman adduct-derived N-cinnamyl-substituted isatin
Sriramoju Bharath Kumar1, Mettu Ravinder1, Golla Kishore2
11Crop Protection Chemicals Division, Indian Institute of Chemical Technology, Uppal Road, Hyderabad, 500607 India.
Abstract:
Baylis-Hillman adduct-derived N-cinnamyl-substituted isatin derivatives were synthesized and evaluated for their antitubercular activity on Mycobacterium tuberculosis H37Rv strain ATCC 27294 by agar dilution method. Anticancer activity for the same compounds was also screened on four different cell lines: Chinese hamster ovary (CHO cells), Colo 205 (human colon cancer), Sup-T1 (human lymphoma) and C6 glioma (rat glioma) by MTT assay method. The compounds (3j-l) have shown significant activity against Mycobacterium strain and the compound 3l has shown specific cytotoxic activity.
More Related Videos
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
Published on: June 20, 2014
07:30A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
Published on: January 21, 2020
Related Concept Videos
Drugs that Stabilize Microtubules
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Drugs that Destabilize Microtubules