Cellulose-based virus-retentive filters: a review

Area of Science:

• Materials Science
• Biotechnology
• Environmental Science

Background:

• Viral filtration is crucial for biopharmaceutical purification, water quality monitoring, and airborne pathogen protection.
• Cellulose-based materials are widely employed in various viral filtration applications due to their properties.

Purpose of the Study:

• To review the use of cellulose-based filter media for viral filtration in biopharmaceutical manufacturing, water analysis, and personal protective equipment.
• To detail the performance data of cellulosic filters in virus reduction and recovery/concentration.
• To explore innovative cellulose-based materials with virucidal properties.

Main Methods:

• Review of existing literature on cellulose-based viral filters.
• Analysis of data from spiking studies quantifying viral filtration performance.
• Survey of viral analysis techniques using cellulose filters, such as the viradel method.

Main Results:

• Regenerated cellulose hollow fiber filters demonstrate significant virus reduction in blood product manufacturing.
• Cellulosic filters, both electropositive and electronegative, are effective for virus recovery and concentration from water samples.
• New cellulose-based materials with virucidal properties are being developed for enhanced protection.

Conclusions:

• Cellulose-based filters are versatile and effective for various viral filtration needs.
• Further development of cellulose materials offers promising advancements in viral filtration technology.
• Cellulosic filters play a vital role in ensuring product safety and public health.