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Updated: Dec 25, 2025

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Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Published on: September 19, 2022
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Solid Phase Synthesis of Dual Labeled Peptides: Development of Cell Permeable Calpain Specific Substrates
Brian M Polster1, Rafael Arze2, Matthew H Lyttle2
12Buck Institute for Age Research, 8001 Redwood Blvd., Novato, CA 94945 USA.
International Journal of Peptide Research and Therapeutics
|March 28, 2020
Abstract:
A step-by-step evaluation of dual-labeled FRET substrates for the protease calpain is reported. The study led to cell permeable selections, with optimized specificity and effectiveness for the target enzyme, and improved stability to non-specific degrading enzymes.

