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Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses
Published on: April 4, 2019
[New and rare pneumotropic viruses]
F C Ringshausen1, G G U Rohde2
11Klinik für Pneumologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Deutschland.
Abstract:
While acute viral respiratory tract infections are one of the major reasons for the loss of productivity among the general population in industrialized nations, they are one of the top killers among infants worldwide, in particular in low-income countries. With the advances in molecular diagnostics and the introduction of high-throughput screening techniques a variety of novel, so far unknown viruses have been discovered from respiratory secretions. However, the clinical significance is often difficult to determine. This review article provides an introduction to those novel viruses which have been described since the beginning of the millennium and discusses the clinical relevance in the light of current scientific evidence. The viruses covered by the present review are human metapneumovirus, human bocavirus, human coronaviruses OC43, 229E, NL63, HKU1, SARS and MERS, human polyomaviruses KI, MC and WU and human parechoviruses.
Insights
Novel respiratory viruses, including human metapneumovirus and bocavirus, are increasingly identified. This review examines their clinical significance in respiratory infections, particularly in infants, using current scientific evidence.
Area of Science:
- Virology
- Infectious Diseases
- Public Health
Context:
- Acute viral respiratory tract infections cause significant productivity loss in industrialized nations.
- These infections are a leading cause of infant mortality globally, especially in low-income countries.
- Advances in molecular diagnostics have led to the discovery of numerous novel respiratory viruses.
Purpose:
- To introduce novel viruses discovered since 2000.
- To discuss the clinical relevance of these novel viruses based on current scientific evidence.
- To provide an overview of human metapneumovirus, human bocavirus, novel human coronaviruses (OC43, 229E, NL63, HKU1, SARS, MERS), human polyomaviruses (KI, MC, WU), and human parechoviruses.
Summary:
- This review details newly identified respiratory viruses such as human metapneumovirus and human bocavirus.
- It evaluates their clinical significance in respiratory illnesses, particularly in vulnerable populations like infants.
- The article synthesizes current scientific data on these emerging viral pathogens.
Impact:
- Enhances understanding of the virome in respiratory infections.
- Informs public health strategies for managing viral respiratory diseases.
- Provides a foundation for future research into the pathogenesis and treatment of novel viral infections.
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