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Maxillo-orbital lymphoma (Burkitt's-type) in an infant Macaca fascicularis
M J Jayo1, J M Jayo, C P Jerome
1Department of Comparative Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27103.
Laboratory Animal Science
|December 1, 1988
Summary
A rapidly growing tumor caused facial deformation and eye proptosis in a young cynomolgus monkey. This malignant lymphoma showed similarities to human Burkitt's lymphoma.
Area of Science:
- Veterinary Pathology
- Comparative Oncology
- Primate Neoplasia
Background:
- Malignant lymphomas are aggressive cancers affecting lymphocytes.
- Burkitt's lymphoma, a type of non-Hodgkin lymphoma, is common in children in equatorial Africa.
Observation:
- A 5-month-old cynomolgus monkey presented with facial deformity and proptosis of the left eye.
- A rapidly growing peribulbar and retro-orbital mass was identified, invading surrounding bone and extending into the brain.
- Histological examination revealed a variable cell population with blast-like neoplastic lymphocytes, histiocytes, and plasmacytoid features, exhibiting a "starry-sky" pattern.
Findings:
- Morphometric analysis of tumor cells showed similarities to human Burkitt's lymphoma cells.
- The tumor was diagnosed as a malignant lymphoma of unknown etiology.
- Electron microscopy confirmed the presence of various neoplastic cell types.
Implications:
- This case highlights the potential for aggressive lymphomas resembling human Burkitt's lymphoma in non-human primates.
- Understanding such comparative oncology cases can provide insights into lymphoma pathogenesis and inform veterinary oncology practices.
- Further research into the etiology of these lymphomas in primates may be warranted.