Endoreplication - a means to an end in cell growth and stress response

Endoreplication, also called endoreduplication or endopolyploidization, is a cell cycle variant in which the genome is re-replicated in the absence of mitosis causing cellular polyploidization. Despite the common occurrence of endoreplication in plants and the tremendous extent in specific tissues and cell types such as the endosperm, the underlying molecular regulation and the physiological consequences have only now started to be understood. Endoreplication is often associated with cell differentiation and withdrawal from mitotic cycles. Recent studies have underlined the importance of endoreplication as a stress response and we summarize here this progress with particular focus on future perspectives offered by the recent advances in genomics and biotechnology.