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Sleep Disordered Breathing in Hypertrophic Cardiomyopathy-Current State and Future Directions

Shreyas Venkataraman1, Shahid Karim1, Aiswarya Rajendran1

  • 1Department of Cardiovascular Medicine, Mayo Clinic, 55905 Rochester, MN 55901, USA.

Journal of Clinical Medicine
|March 29, 2020
PubMed

Insights

Sleep disordered breathing (SDB) is common in hypertrophic cardiomyopathy (HCM) and worsens outcomes. Treating SDB, like obstructive sleep apnea (OSA), may improve cardiovascular health in HCM patients.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Genetics

Background:

  • Hypertrophic cardiomyopathy (HCM) is a primary inherited heart muscle disease.
  • Sleep disordered breathing (SDB) frequently co-exists with HCM.
  • SDB is a modifiable risk factor linked to increased mortality and morbidity in cardiovascular diseases.

Purpose of the Study:

  • To review the co-occurrence of HCM and SDB.
  • To explore the pathophysiology of SDB in HCM, including its impact on heart failure, arrhythmias, ischemia, and pulmonary hypertension.
  • To discuss current and future therapeutic strategies for SDB in HCM.

Main Methods:

  • Literature review of studies on HCM and SDB.
  • Analysis of pathophysiological mechanisms linking SDB to cardiovascular complications in HCM.
  • Evaluation of therapeutic interventions for SDB and their effects on HCM.

Main Results:

  • SDB is prevalent in HCM patients.
  • SDB contributes to adverse cardiovascular outcomes in HCM through various mechanisms.
  • Treatment of obstructive sleep apnea (OSA), a common form of SDB, shows potential benefits for HCM.

Conclusions:

  • SDB is a significant comorbidity in HCM.
  • Understanding the pathophysiology is crucial for management.
  • Targeting SDB, particularly OSA, represents a promising therapeutic avenue for improving HCM patient outcomes.

Keywords:
Sleep apneahypertrophic cardiomyopathysleep-disordered breathing

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